The Candy Shop rapper, who was being quizzed by South Asian fusion website desihits.com, caused uproar by making the sexually provocative motion while being taught chat-up lines.
As 50 was shown how to say 'beautiful girl' in Hindi, he loosened his 'fly' and interrupted: "Everyone around the world knows sign language. I am looking forward to coming to India. Every country I have been to, even if I don't speak the language, people know what I mean when I do this."
The visibly stunned male interviewer covered his face with his hands as he said: "Stop 50, you are really embarrassing me. I can't believe 50 just tried to show us his wicket!"
The presenter hastily made 50 return to his seat before cutting to a music video.
One horrified female viewer said: "What 50 did was totally unacceptable. I couldn't believe he could be so inappropriate during an interview."
50 also revealed he is set to release his own range of incense.
The hip-hop star is considering launching a line of aromatic oils and sticks under the name '50 Scent'.
He said: "You know what, this could be cool. I like this idea."
pmpl da oman deh remind a di oman inna di vid bout "does size matter" mad fiddy! mi nah buy dat stil. man inspired from the smell o him balls. who to tell...dat cud be his main ingredient