Arsenal must take on the fearsome Barcelona in the UEFA Champions League following the draw in Nyon on Friday.
The Gunners' English counterparts Manchester United face French side Marseille, while Chelsea will be satisfied to have drawn Danish outfit FC Copenhagen. Tottenham may not be so happy to have drawn AC Milan, a return to San Siro where they faced Inter in the group stage.
Elsewhere, current champions Inter Milan and their boss Rafael Benitez will stage a rematch of last season's final against German giants Bayern Munich. Jose Mourinho's Real Madrid will face Lyon while Italian outfit Roma meet FC Shakhtar Donetsk.
Arsene Wenger's Arsenal probably got the toughest draw possible, having finished second to Shakhtar Donetsk in their group despite boasting three wins after three group games.
Last season they crashed out of the competition against Pep Guardiola's team and the brilliant Lionel Messi as Barca were went on to be beaten by Inter Milan in the semi-finals.
Following their concluding group win over Partizan Belgrade, Arsenal duo Robin van Persie and Theo Walcott said they would love to face Barcelona - and now their wish has been granted.
Arsenal secretary David Miles said: "Every draw would have been hard but if we're being honest Barcelona are probably the form team in Europe this season.
"It'll be two great teams playing attacking football and we're looking forward to it. Hopefully we can turn the tables on them this time."
Manchester United, Chelsea and to a lesser degree Tottenham were all rewarded for winning their respective groups with relatively kind draws. Sir Alex Ferguson's Manchester United and Carlo Ancelotti's Chelsea will be particularly confident of making it into the quarter-finals.
UEFA Champions League Round of 16 draw
FC Roma v FC Shakhtar Donetsk AC Milan v Tottenham Hotspur Valencia v Schalke 04 Inter Milan v Bayern Munich Lyon v Real Madrid Arsenal v Barcelona Marseille v Manchester United FC Copenhagen v Chelsea
-- Edited by I-CO on Friday 17th of December 2010 06:50:52 PM