Washington (CNN) -- The availability of illegal drugs is increasing in the United States -- fueled largely by expanding activity from Mexican drug cartels -- and abuse of controlled prescription drugs is getting worse, according to the National Drug Threat Assessment 2010 report, released Thursday.

"The trafficking and abuse of drugs affects everyone," said Michael T. Walther, director of the Justice Department's National Drug Intelligence Center, which produced the report. "The economic cost alone is estimated at nearly $215 billion annually."

The Mexican cartels, the report says, are "the single greatest drug trafficking threat to the United States." The Mexican organizations have operations in every region of the United States and are expanding into more rural and suburban areas.

They've also stepped up cooperation with U.S. street and prison gangs for distribution.